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To serve patients, health care providers, research scientists, scholars, and society by providing excellence and innovation in diagnostic services and educational resources in a respectful, professional and culturally diverse atmosphere.

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To become a preeminent leader in academic anatomic and clinical pathology while translating basic science discovery to improved clinical care.



Daynna Wolff, Ph.D. - Director of Cytogenetics
Daynna J. Wolff, Ph.D.

Professor
Director of Cytogenetics and Molecular Genetics
Department of Pathology & Laboratory Medicine
Office: Childrens Hospital Room 222C
Phone: (843) 792-3574
Fax: (843) 792-1248

CLINICAL EXPERTISE:

Clinical Cytogenetics
Molecular Genetics
Cytogenomic Microarray Analysis
Laboratory Quality Assurance

EDUCATION:

B.A., 1985, College of Notre Dame of Maryland, Baltimore
Ph.D., 1991, Division of Human Genetics, University of Maryland at Baltimore
Post-Doctoral Fellowship, 1992, Department of Genetics, Stanford University
1993-1995, Clinical Cytogenetics and Clinical Molecular Genetics Fellow, Center for Human Genetics, Case Western University, Cleveland, Ohio

RESEARCH INTERESTS:

Cytogenomic microarray analysis of cancers
Oncology biomarkers

RECENT PUBLICATIONS:

  1. Forcucci JA, Sugianto JZ, Wolff DJ, Maize JC Sr, Ralston JS. “Low-Fat" Pseudoangiomatous Spindle Cell Lipoma: A Rare Variant with Loss of 13q14 Region. Am J Dermatopathol. 2015 Feb 10 [Epub ahead of print]
  2. Grosu DS, Hague L, Chelliserry M, Little KM, Lenta R, Klotzle B, San J, Goldstein WM, Moturi S, Devers P, Woolworth J, Peters E, Elashoff B, Sterker J, Wolff DJ, Friedman KJ, Highsmith WE, and One FS. Clinical investigational studies for validation of next-generation sequencing (NGS) in vitro diagnostic (IVD) for cystic fibrosis (CF) testing. Expert Rev Mol Diagn. 2014. 14(5)605-22
  3. Dimashkieh H, Wolff DJ, Smith TM, Houser PM, Nietert PJ, Yang J. Evaluation of urovysion and cytology for bladder cancer detection: a study of 1835 paired urine samples with clinical and histologic correlation. Cancer Cytopathol 121(10): 591-597, 2013.
  4. Cooley LD, Lebo M, Li MM, Slovak ML, Wolff DJ. American College of Medical Genetics and Genomics technical standards and guidelines: microarray analysis for chromosome abnormalities in neoplastic disorders. Working Group of the American College of Medical Genetics and Genomics (ACMG) Laboratory Quality Assurance Committee. Genet Med 15(6): 484-494, 2013.
  5. Saxe DF, Persons DL, Wolff DJ, Theil KS. Validation of fluorescence in situ hybridization using an analyte-specific reagent for detection of abnormalities involving the mixed lineage leukemia gene. Arch Pathol Lab Med 136:47-52, 2012.
  6. Butler C, Wolff DJ, Kang Y, Stuart RK, Costa LJ. Association of age with fluorescence in situ hybridization abnormalities in multiple myeloma reveals higher rate of IGH translocations among older patients. Leuk Lymphoma. 2012 Dec;53(12):2444-8.
  7. Quigley DI, Foster JA, Carter SN, Wolff DJ. Cytogenetics caseload survey summary 2012. J Assoc Genet Technol. 2012;38(4):199-202.
  8. Kearney HM, South ST, Wolff DJ, Lamb A, Hamosh A, Rao KW. ACMG recommendations for the design and performance expectations for clinical genomic copy number microarrays intended for use in the postnatal setting for detection of constitutional abnormalities. Genet Med 13:676-679, 2011.
  9. Zhang L, Znokyo I, Costa LJ, Conlin LK, Daber R. Self S, Wolff DJ. Clonal diversity using SNP microarrays: A new prognostic marker for chronic lymphocytic leukemia. Cancer Genetics, 2011 Dec; 204(12):654-65.
  10. Zhang L Chan SSL, Wolff DJ. Mitochondrial Disorders of DNA Polymerase g Dysfunction: From Anatomic to Molecular Pathology Diagnosis. Arch Path Lab Med, 135:925-934, 2011.
  11. Post G, Black JS, Cortes GY, Pollack RB, Wolff DJ, Lazarchick J. The utility of fluorescence in situ hybridization (FISH) analysis in diagnosing graft versus host disease following orthotopic liver transplant. Ann Clin Lab Sci, 41:188-92, 2011.
  12. Brothman AR,Dolan MM, Goodman BK, Park JP, Persons DL, Saxe DF, Tepperberg JH, Tsuchiya KD, Van Dyke DL, Wilson KS, Wolff DJ, Theil KS. CAP/ACMG proficiency testing for constitutional cytogenomic microarray analysis. Genetics in Med, 13:765-769, 2011.
  13. Wolff, DJ, Van Dyke, DL, Powell CM and the Working Group of the ACMG Laboratory Quality Assurance Committee. Laboratory Guideline for Turner syndrome. Genet Med. 12:52-55, 2010.
  14. Wolff DJ, Heaney DL, Neuwald PD, Stellrecht KA, Press RD. Multi-Site PCR-based CMV viral load assessment-assays demonstrate linearity and precision, but lack numeric standardization: a report of the association for molecular pathology. J Mol Diagn. 11:87-92, 2009.

INVITED REVIEW MANUSCRIPTS:

  1. Wolff DJ. Advances in laboratory evaluation of Turner syndrome and its variants: Beyond cytogenetics studies. Indian J Peds 67:825-830, 2000.
  2. Laudadio J, Quigley DI, Tubbs R, Wolff DJ. HER2 testing: A review of detection methodologies and their clinical performance. Expert Rev Mol Diagn.7:53-64, 2007.
  3. Wolff DJ. The Genetics of bladder cancer: A cytogeneticist’s perspective. Cytogenet Genome Res.118(2-4):177-81, 2007.

BOOK CHAPTERS:

  1. Wolff DJ, Brothman A, Hirsch B, Jacky P. Clinical Cytogenetics. In, American College of Medical Genetics Standards and Guidelines for Clinical Genetics Laboratories, edited by M Watson, www.acmg.net, 2004.
  2. Wolff DJ, Schwartz S. Clinical Applications of Fluorescence In Situ Hybridization. In, The Principles of Clinical Cytogenetics, Second Edition, edited by S.Gerson and M Keagle. Humana Press, Inc., Totowa, NJ, 2005.
  3. Wolff DJ. Advances in Clinical Cytogenetics. In, Encyclopedia of Genomics, Proteomics and Bioinformatics, edited by M Dunn, L Jorde, P Little and S Subramaniam. John Wiley & Sons, Ltd., West Sussex, UK, 2006.


Carroll A. Campbell, Jr. Neuropathology Laboratory (Brain Bank)

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