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To serve patients, health care providers, research scientists, scholars, and society by providing excellence and innovation in diagnostic services and educational resources in a respectful, professional and culturally diverse atmosphere.

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To become a preeminent leader in academic anatomic and clinical pathology while translating basic science discovery to improved clinical care.



Shaoli Sun, M.D.

Shaoli Sun, M.D.

Clinical Professor
Department of Pathology & Laboratory Medicine
Office: Children's Hospital Room 304A
Phone: (843) 792-7879
Fax: (843) 792-7060

CLINICAL EXPERTISE:

Gastrointestinal Pathology
Liver Pathology

EDUCATION:

M.D., 1984, Henan Medical University, Zhengzhou, China
Pathology Residency: 1993-1997, Mount Sinai Hospital, New York, NY
PostDoctoral Fellowship in Cancer Research: 1998-1999, Fred Hutchinson Cancer Research Center, Seattle, WA

RESEARCH INTERESTS:

Cancer Immunology

SELECTED PUBLICATIONS:

  1. Zhang Y, Wu BX, Metelli A, Thaxton JE, Hong F, Rachidi S, Ansa-Addo E, Sun S, Vasu C, Yang Y, Liu B, Li Z. GP96 is a GARP chaperone and controls regulatory T cell functions. J Clin Invest. 2015 Feb;125(2):859-69. doi: 10.1172/JCI79014. Epub 2015 Jan 20.
  2. Rachidi S, Sun S, Wu BX, Jones E, Drake RR, Ogretmen B, Cowart LA, Clarke CJ, Hannun YA, Chiosis G, Liu B, Li Z. Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis. J Hepatol. 2015 Apr;62(4):879-88. doi: 10.1016/j.jhep.2014.11.010. Epub 2014 Nov 22.
  3. Rachidi S, Sun S, Li Z. Endoplasmic reticulum heat shock protein gp96/grp94 is a pro-oncogenic chaperone, not a tumor suppressor. Hepatology. 2014 Aug 28. Doi: 10.1002/ep.27400
  4. Morales C, Rachidi S, Hong F, Sun S, Ouyang X, Wallace C, Zhang Y, Garrett-Mayer E, Wu J, Liu B, Li Z. Immune chaperone gp96 drives the contributions of macrophages to inflammatory colon tumorigenesis. Cancer Res. 2014, Jan 15; 74(2):446-459. doi: 10.1158/0008-5472.CAN-13-1677. Epub 2013 Dec. 9.
  5. Zhang Y, Helke KL, Coelho SG, Valencia JC, Hearing VJ, Sun S, Liu B, Li Z. Essential role of the molecular chaperone gp96 in regulating melanogenesis. Pigment Cell Melanoma Res., 2014, Jan; 27(1):82-89. doi: 10.1111/pcmr.12165. Epub 2013, October 9.
  6. Robinson JC, Hoffman B and Sun S*. Gastric Adenomas: Subtypes and their Clinical Significance. Pathology Case Reviews. 2013 March/April: 18(2):70-74 (* corresponding author).
  7. Liu G, Lu S, Wang X, Page ST, Higano CS, Plymate SR, Greenberg NM, Sun S, Li Z, Wu JD. Perturbation of NK cell peripheral homeostasis accelerates prostate carcinoma metastatis. J Clin Invest. 2013, October 1; 123(10): 4410-22. doi: 10.1172/JCI69369. Epub 2013, Sept. 9.
  8. Knackstedt R, Shaoli S, Moseley V, Wargovich M. The importance of the retinoid X receptor alpha in modulating inflammatory signaling in acute murine colitis. Dig Dis Sci. 2014 Apr; 59(4): 753-739. doi: 10.1007/s10620-013-2902-8. Epub 2013, October 22.
  9. Liu B, Staron M, Hong F, Wu BX, Sun S, Morales C, Crosson CE, Tomlinson S, Kim I, Wu D, Li Z: Essential Roles of grp94 in Gut homeostasis via Chaperoning Canonical Wnt Pathway. Proc Natl Acad Sci USA, 2013, April 9: 110(17):6877-6882.
  10. Knackstedt R, Moseley VR, Sun S, Wargovich MJ. Vitamin D Receptor and Retinoid X Receptor Alpha Status and Vitamin D Insufficiency in Models of Murine Colitis. Cancer Prev Res 2013. April 12 {Epub ahead of print}.
  11. Rachidi SM, Qin T, Sun S, Zheng WJ, Li Z. Molecular Profiling of Multiple Human Cancers Defines an Inflammatory Cancer-Associated Molecular Pattern and Uncovers KPNA2 as a Uniform Poor Prognostic Cancer Marker. PLoS One. 2013. 8(3):e57911.doi: 10.1371/journal.pone.0057911, Epub 2013, March 25.
  12. Daniels JA, Gibson MK, Xu L, Shaoli Sun, Canto MI, Heath E, Wang J, Brock M, Montgomery E: Gastrointestinal tract epithelial changes associated with taxanes: marker of drug toxicity versus effect. Am J Surg Pathol 2008 Mar;32(3):473-7.
  13. Dai J, Liu B, Ngoi SM, Shaoli Sun, Vella AT, Li Z: TLR4 hyperresponsiveness via cell surface expression of heat shock protein gp96 potentiates suppressive function of regulatory T cells. ] Immunol 2007 Mar 1;178(5):3219-25.
  14. Liu B, Dai J, Zheng H, Stoilova D, Shaoli Sun, Li Z: Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases. Proc Natl Acad Sci USA 2003 Dec 23;100(26):15824-9.
  15. Silletti RP. Ailey E, Shaoli Sun and Tang D: Microbiologic and clinical value of primary broth cultures of wound specimens collected with swabs. J Clin Microbiol 1997 Aug; 35(8): 2003-6.
  16. Shaoli Sun, Liu YJ and Li Z: The differentiation of human dendritic cells associates with the induction of heat-shock proteins. Scand J Immunol 2001 July; 54(suppl 1):26.
  17. Kemp CJ, Shaoli Sun and Gurley KE: p53 induction and apoptosis in response to radio- and chemotherapy in vivo is tumor-type-dependent. Cancer Research 2001 Jan; 61(1):327-32.
  18. Han JS, Chen XH, Shaoli Sun, Xu XJ, Yuan Y, Yan SC, Hao JX and Terenius L: Effect of low and high-frequency TENS on Met-enkephalin-Arg-Phe and dynorphin A immunoreactivity in human lumbar CSF. Pain. 1991 Dec;47(3):295-8.
  19. Shaoli Sun and Han JS: High and low frequency electroacupuncture analgesia are mediated by different types of opioid receptors at spinal level: a cross - tolerance study. Acta Physiologica Sinica. 1989 Aug; 41(4):416-20.


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