To serve patients, health care providers, research scientists, scholars, and society by providing excellence and innovation in diagnostic services and educational resources in a respectful, professional and culturally diverse atmosphere.
To become a preeminent leader in academic anatomic and clinical pathology while translating basic science discovery to improved clinical care.
Bradley A. Schulte, Ph.D.
Vice Chair for Research
Professor, Department of Pathology & Laboratory Medicine
Professor, Department of Otolaryngology/Head and Neck Surgery
Department of Pathology & Laboratory Medicine
Office: Walton Research Building Room 812
Phone: (843) 792-2704
Fax: (843) 792-0368
B.A., 1975, Winona State University
Ph.D., 1980, University of Minnesota
Our laboratory conducts basic biomedical research aimed at defining the molecular and cellular mechanisms responsible for generating the unique ionic and electrochemical gradients in the inner ear. Biochemical and histochemical techniques are used to identify and determine the precise cellular distribution of ion transport mediators and their associated regulatory proteins. Emphasis is placed on relating changes in auditory function with alterations in the expression of key proteins promoted by disease, noise-trauma and aging. In vivo and in vitro studies are conducted using mouse and gerbil animal models. Recent work focuses on direct correlational studies of human auditory performance with genetic variation and histopathological changes in the human inner ear.
Work in the laboratory is supported in part by grants R01 DC00713 and P50 DC00422 from the National Institute on Deafness and Other Communication Disorders.
Lang H, Schulte BA, Schmiedt RA (2005). Ouabain induces apoptotic cell death in type I spiral ganglion neurons, but not type II neurons. JARO 6:63-74. PMCD: PMC2504640
Spicer SS, Schulte BA (2005). Pathologic changes of presbyacusis begin in secondary processes and spread to primary processes of strial marginal cells. Hearing Res, 205:225-240. PMID: 15953531
Liang F, Schulte BA, Qu C, Hu W, Shen Z (2005). Inhibition of the calcium- and voltage-dependent big conductance potassium channel ameliorates cisplatin-induced apoptosis in spiral ligamant fibrocytes of the cochlea. Neuroscience 135:263-271. PMID: 16109459
Wang Y, Schulte BA, Ogawa M, Zhou D (2006). Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood 107(1): 358-366. PMCID: PMC1895367
Qu C, Liang F, Hu W, Shen Z, Spicer SS, Schulte BA (2006). Expression of CLC-K chloride channels in the rat cochlea. Hearing Res 213:79-87. PMID: 16566872
Lang H, Ebihara Y, Schmiedt RA, Minamiguchi H, Zhou D, Smythe N, Liu L, Ogawa M, Schulte BA (2006). Contribution of bone marrow hematopoietic stem cells to adult mouse inner ear: Mesenchymal cells and fibrocytes. J Comparative Neurol 496:187-201. PMCID: PMC2561311
Lang H, Schulte BA, Zhou D, Smythe N, Spicer SS, Schmiedt RA (2006). Nuclear-Factor Kappa B deficiency is associated with auditory nerve degeneration and increased noise-induced hearing loss. J Neurosci 26(13):3541-3550. PMCID: PMC2897814
Mills JH, Schmiedt RA, Schulte BA, Dubno JR (2006). Age-related hearing loss: A loss of voltage, not hair cells. In: Seminars in Hearing 27,228-236.
Qu C, Liang F, Smythe NM, Schulte BA (2007). Identification of CIC-2 and CIC-K2 chloride channels in cultured rat type IV spiral ligament fibrocytes. JARO 8: 205-219. PMCID: PMC2538352
Spicer SS, Qu C, Smythe N, Schulte BA (2007). Mitochondria-activated cisternae generate the cell specific vesicles in auditory hair cells. Hear Res 233: 40-45. PMCID: PMC2888100
Lang H, Schulte BA, Goddard JC, Hedrick M, Yu Shanping, Wei L, Schmiedt RA (2008). Transplantation of mouse embryonic stem cells into the cochlea of an auditory-neuropathy animal model: Effects of timing after injury. JARO 9(2):225-240. PMCID: PMC2504604.
Sera Y, LaRue AC, Moussa O, Mehrotra M, Duncan JD, Williams CR, Nishimoto E. Schulte BA, Watson, PM, Watson DK, Ogawa M (2009). Hematopoietic stem cell origin of adipocytes. Exp Hematol 37:1108-1120. PMCID: PMC2740899.
Lang H. Jyothi V, Smythe NM, Dubno JR, Schulte BA, Schmiedt RA (2010). Chronic Reduction of Endocochlear potential reduces auditory nerve activity. Further confirmation of an animal model of metabolic presbyacus. JARO 11(3), 419-434. PMCID: PMC2914241.
Jyothi V, Li M, Kilpatrick LA, LaRue AC, Zhou D, Schulte BA, Schmiedt RA, Lang H (2010). Unmyelinated auditory type I spiral ganglion neurons in congenic Ly5.1 mice. J Comp Neuro, 518(16), 3254-71. PMCID: PMC2897057.
Xing Y, Samuvel DJ, Stevens SM, Dubno JR, Schulte BA, Lang H (2012). Age-related changes in myelin basic protein in mouse and human auditory nerve. PLoS ONE. In press. PMCID: PMC3320625