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To serve patients, health care providers, research scientists, scholars, and society by providing excellence and innovation in diagnostic services and educational resources in a respectful, professional and culturally diverse atmosphere.

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To become a preeminent leader in academic anatomic and clinical pathology while translating basic science discovery to improved clinical care.



Steven L. Carroll, M.D., Ph.D.

Steven L. Carroll, M.D., Ph.D.

Campus Address:
Phone: 843-792-3121

FACULTY APPOINTMENTS

Type Deparment/Center/School Division Rank
Primary Pathology and Laboratory Medicine General Administration Professor and Chair
Secondary College of Graduate Studies Professor
Center Hollings Cancer Center Cancer Genes and Molecular Regulation

LICENSURE AND BOARD CERTIFICATIONS:

South Carolina Medical License
Alabama Medical License
Missouri Medical License
American Board of Pathology - Certified in Anatomic Pathology
American Board of Pathology - Special Qualification in Neuropathology

BIOGRAPHICAL SKETCH:

Dr. Steven Carroll is Professor and Chair of the Department of Pathology and Laboratory Medicine and a Research Member of the MUSC Comprehensive Cancer Center’s Cancer Genes and Molecular Regulation Program. Dr. Carroll’s research program, which is funded by NINDS, NCI, the DOD and the Children’s Tumor Foundation, is focused on the mechanisms underlying the pathogenesis of neurofibromatosis type 1-associated peripheral nerve sheath tumors and the development of new therapies for these neoplasms. Dr. Carroll serves as an Associate Editor for the Journal of Neuropathology and Experimental Neurology and has served on the editorial boards of several journals including Neuro-Oncology and The American Journal of Pathology.

Dr. Carroll received his B.S. degree from the University of Memphis in 1981. He then attended Baylor College of Medicine, receiving his Ph.D. in Cell Biology in 1986 and his M.D. in 1988. Dr. Carroll’s postdoctoral research fellowship, Anatomic Pathology Residency and Neuropathology Fellowship were performed at the Washington University School of Medicine (1988-1994). Prior to his arrival at MUSC, Dr. Carroll was Professor of Pathology, Neurobiology and Cell Biology at the University of Alabama at Birmingham (UAB) and the Director of the UAB Division of Neuropathology. While at UAB, Dr. Carroll served as an attending neuropathologist at the University of Alabama Hospital, the Birmingham VA, UAB Highlands Hospital and Alabama Children’s Hospital. He was a Scientist in the UAB Alzheimer’s Disease Research Center, the Mental Retardation Research Center, the Center for Aging, the Center for Glial Biology in Medicine, the Civitan International Research Center and the Center for Neurodegeneration and Experimental Therapeutics as well as being as a Member of the Comprehensive Neuroscience Center and a Senior Scientist in the UAB Comprehensive Cancer Center. Dr. Carroll is certified by the American Board of Pathology in Anatomic Pathology and Neuropathology.

SOCIETY MEMBERSHIPS

Organization Position Held Link
American Association for the Advancement of Science www.aaas.org
American Association for Cancer Research www.aacr.org
American Association of Neuropathologists www.neuropath.org
American Pathology Foundation www.apfconnect.org
American Society for Investigative Pathology www.asip.org
American Society for Neurochemistry www.asneurochem.org
Association of Pathology Chairs www.apcprods.org
Society for Neuro-Oncology www.soc-neuro-onc.org
Society for Neuroscience www.sfn.org
Southern Working Association of Neuropathologists
The Histochemical Society www.histochemicalsociety.org

EDITORSHIPS AND EDITORIAL BOARDS:

Dates Journal Position Held
2013-2016 Journal of Neuropathology and Experimental Neurology Associate Editor
2013-2015 Journal of Neuropathology and Experimental Neurology Editorial Board Member
2012-2015 Neuro-Oncology Editorial Board Member
2011-2012 Brain Research Bulletin Guest Editor, “Genetically Engineered Mouse Models of Neurologic Diseases”
2010-2012 Brain Research Bulletin Section Editor (Neurobiology of Disease)
2010-2012 Brain Research Bulletin Section Editor (Development and Repair)
2007- The American Journal of Pathology Editorial Board Member
2006-2012 Brain Research Bulletin Editorial Board Member
2000-2005 Journal of Neuropathology and Experimental Neurology Editorial Board Member

RESEARCH/CLINICAL INTEREST:

Title
Genomic, epigenetic and signaling abnormalities driving the pathogenesis of neurofibromatosis type-1 and -2 associated peripheral nerve sheath tumors

Description
The Carroll laboratory is focused on determining what molecular abnormalities are responsible for the development of schwannomas, plexiform neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs) and using this information to develop effective new treatments for these neoplasms. We have found evidence that abnormal signaling by neuregulin-1 (NRG1), a potent Schwann cell growth factor, promotes the pathogenesis of these peripheral nerve sheath tumors in humans. Based on this evidence, we have developed a novel genetically engineered mouse model in which inappropriate expression of NRG1 in Schwann cells results in the development of large numbers of plexiform neurofibromas. In contrast to previously developed Nf1 knockout mouse models, the plexiform neurofibromas occurring in our genetically engineered mice progress to become MPNSTs at a very high frequency. This animal model thus gives us a unique opportunity to establish both what abnormalities drive the development of plexiform neurofibromas and to determine what subsequent changes cause plexiform neurofibromas to undergo malignant transformation. Using this model and an orthotopic xenograft model we have also developed, we have identified three novel classes of compounds that effectively inhibit the growth of plexiform neurofibromas and MPNSTs in culture and in vivo. To identify additional therapeutic targets in NF-associated peripheral nerve sheath tumors, we are also using NextGen sequencing methods to comprehensively identify all of the genetic changes (mutations) and epigenetic abnormalities driving the development of peripheral nerve sheath tumors; these studies are being performed using tumors collected from human NF patients and tumors developing in our NRG1 overexpressing mouse model. These comprehensive approaches thus continue to identify potential new treatment targets, thereby laying the groundwork for the development of effective new therapies for NF-associated tumors.

KEYWORDS:

Cancer biology, neurodegenerative diseases, neuropathology, neurofibromatosis, cancer genomics

SELECTED PUBLICATIONS:

  1. Evaluation of the safety and biodistribution of M032, an attenuated HSV-1 virus expressing hIL-12, after intracerebral administration to Aotus non-human primates. Roth JC, Cassady KA, Cody JJ, Parker JN, Price KH, Coleman JM, Peggins JO, Noker PE, Powers NW, Grimes SD, Fulton R, Carroll SL, Gillespie GY, Whitley RJ and Markert JM. Human Gene Therapy Clinical Development 2014; 25(1): 16-27. PMID: 24649838
  2. Benitez BA, Jin SC, Guerreiro R, Graham R, Lord J, Harold D, Sims R, Lambert JC, GibbsJR, Bras J, Sassi C, Harari O, Bertelsen S, Lupton MK, Powell J, Bellenguez C, Brown K, Medway C, Haddick PC, van der Brug MP, Bhangale T, Ortmann W, Behrens T, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Haines JL, Turton J, Braae A, Barber I, Fagan AM, Holtzman DM, Morris JC, The 3C Study Group, the EADI Consortium, the Alzheimer’s Disease Genetics Consortium (ADGC)*, Alzheimer’s Disease Neuroimaging Initiative (ADNI), the GERAD Consortium, Williams J, Kauwe JS, Amouyel P, Morgan K, Singleton A, Hardy J, Goate AM and Cruchaga C. Missense variant in TREML2 protects against Alzheimer’s disease. Neurobiology of Aging 2014; 35: 1510.e19-150.e26. PMID: 24439484 PMCID: PMC3961557 *Carroll SL appears in the authorship as a member of the Alzheimer’s Disease Genetics Consortium.
  3. Brosius SN, Turk AN, Byer SJ, Brossier NM, Kohli L, Whitmire A, Mikhail FM, Roth KA andCarroll SL. Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesis. Acta Neuropathologica 2014; 127: 573-591. PMID: 24232507
  4. Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager PL, Farrer LA, Saykin AJ, Shulman JM, Naj A, Green RC, GENAROAD Consortium, The Alzheimer’s Disease Neuroimaging Initiative and The Alzheimer’s Disease Genetics Consortium*. Genome-wide association study of the rate of cognitive decline in Alzheimer’s disease. Alzheimer’s and Dementia: The Journal of the Alzheimer’s Association 2014; 10(1): 45-52. PMID: 23535033 PMCID: PMC3760995 *Carroll SL appears in the authorship as a member of the Alzheimer’s Disease Genetics Consortium.
  5. Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, Jun G, DeStefano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Hollingworth P, Ramirez A, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Carlos Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Naranjo MCD, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F, European Alzheimer’s Disease Initiative (EADI), Genetic and Environmental Risk in Alzheimer’s Disease (GERAD), Carney RM, Mash DC, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barmada MM, Barnes LL, Beach TG, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burk JR, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chibnik LB, Chui HC, Clark DG, Corneveaux J, Cribbs DG, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilman S, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Karydas A, Kauwe JSK, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, Kramer P, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lyketsos CG, Mack WJ, Marson DC, Martiniuk F, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, The Alzheimer’s Disease Neuroimaging Initiative (ADNI), Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Yu CE, Barber R, Alzheimer’s Disease Genetic Consortium (ADGC), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannfelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O’Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley Jr TH, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JSK, Boerwinkle E, Riemenschneider M, Boada M, Hiltunen M, Martin ER, Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina V, Seshadri S, Williams J, Schellenberg GD and Amouyel P. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease. Nature Genetics 2013; 45(12): 1452-1458. PMID: 24162737 24162737 PMCID: PMC3896259
  6. Ridge PG, Mukherjee S, Crane P, Kauwe JSK, Albert MS, Albin RL, Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Barnes LL, Beach TG, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, Cruchaga C, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Evans D, Faber KM, Fallon KB, Farlow MR, Farrer LA, Ferris S, Foroud TM, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Glass JD, Goate AM, Graff-Radford NR, Green RC, Growdon JH, Haines JL, Hakonarson H, Hamilton-Nelson KL, Hamilton RL, Hardy J, Harrell LE, Head E, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, Kramer P, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, Mayeux R, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Myers AJ, Naj AC, Olichney JM, Pankratz VS, Parisi JE, Pericak-Vance MA, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schellenberg GD, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Wright CB, Younkin SG, Yu CE and Yu L. Alzheimer’s disease: analyzing the missing heritability. PLoS One 2013; 8(11): e79771.doi: 10.1371/journal.pone.0079771. PMID: 24244562 PMCID: PMC3820606
  7. Kohli L, Kaza N, Coric T, Byer SJ, Brossier NM, Bjornsti MA, Carroll SL and Roth KA. 4-hydroxy-tamoxifen induces autophagic death through K-Ras degradation. Cancer Research 2013; 73(14): 4395-4405. PMID: 23722551 PMCID: PMC3715566
  8. Reitz C, Tosto G, Vardarajan B, Rogaeva E, Ghani M, Rogers RS, Conrad C, Haines JL, Pericak-Vance MA, Fallin MD, Foroud T, Farrer LA, Schellenberg GD, St. George-Hyslop P, Mayeux R, Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Beach TG, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buros J, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Cotman CW, Crane PK, Crocco EA, Cruchaga C, Cummings JL, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Diaz-Arrastia R, Dick M, Dickson DW, Duara R, Ellis WG, Ertekin-Taner N, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Goate AM, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karlawish J, Karydas A, Kauwe JSK, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer P, Kukull WA, Lah JJ, Larson EB, Levey AI, Lieberman AP, Lopez OL, Lunetta KL, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Naj AC, Nowotny P, Parisi JE, Peskind E, Petersen RC, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Shelanski ML, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Valladares O, Van Deerlin VM, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Wright CB, Younkin SG. Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP). Translational Psychiatry 2013; 3: e256. doi: 10.1038/tp.2013.13. PMID: 23673467 PMCID: PMC3669917
  9. Cruchaga C, Kauwe JSK, Harari O, Jin SC, Cai Y, Karch CM, Benitez B, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, Chibnik L, Bennett DA, Arnold SE, Harold D, Sims R, Gerrish A, Williams J, Van Deerlin VM, Lee VMY, Shaw LM, Trojanowski JQ, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Peskind ER, Galasko D, Fagan AM, Holtzman DM, Morris JC, the GERAD Consortium, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Albert MS, Albin RL, Apostolova LG, Baldwin CT, Barmada MM, Barnes LL, Beach TG, Beecham GW, Beekly D, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Crane PK, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch MP, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Glass JD, Goate AM, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hamilton RL, Hamilton-Nelson KL, Hardy J, Harrell LE, Head E, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, Kramer P, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Murrell JR, Myers AJ, Naj AC, Olichney JM, Pankratz VS, Parisi JE, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Troncoso JC, Tsuang DW, Valladares O, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Wang LS, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L and Goate AM. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer’s disease. Neuron 2013; 78(2) 256-268. PMID: 23562540 PMCID: PMC3664945
  10. Reitz C, Jun G, Naj AC, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue MW, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RCP, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Mayeux R, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada MM, Beach TG, Beecham GW, Beekly D, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cao C, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, Cruchaga C, DeCarli C, DeKosky ST, Demirci FY, Dick M, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Glass JD, Growdon JH, Hakonarson H, Hamilton RL, Hamilton-Nelson K, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Karlawish J, Karydas A, Kauwe JSK, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer P, LaFerla FM, Lah JJ, Lang-Walker R, Leverenz JB, Levey AI, Li G, Lieberman AP, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Olichney JM, Parisi JE, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Wright CB, Younkin SG, Yu CE and Yu L. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E e4, and the risk of late-onset Alzheimer disease in African Americans. Journal of the American Medical Association 2013; 309(14): 1483-1492. PMID: 23571587 PMCID: PMC3667653
  11. Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Moriaha T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Wakutani Y, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim JW, Na DL, Ki CS, Seo SW, Mook-Jung I, Albert MS, Albin RL, Apostolova LG, Arnold SE, Baldwin CT, Barber R, Barmada MM, Barnes LL, Beach TG, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, De Jager PL, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Evans D, Faber KM, Fallon KB, Farlow MR, Ferris S, Foroud TM, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Glass JD, Goate AM, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hamilton-Nelson KL, Hamilton RL, Hardy J, Harrell LE, Head E, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Kamboh MI, Karydas A, Kauwe JSK, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, Kramer P, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Leverenz JB, Levey AI, Li G, Lin CF, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Myers AJ, Naj AC, Olichney JM, Pankratz VS, Parisi JE, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Rajbhandary RA, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Tsuang DW, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA and Kuwano R. SORL1 is genetically associated with late-onset Alzheimer’s disease in Japanese, Koreans and Caucasians. PLoS One 2013; 8(4): e58618 doi:10.1371/journal.pone.0058618. PMID: 23565137 PMCID: PMC3614978 Correction: PLoS One 2013; 8(7): doi.10.1371/annotation/fcb56ea7-d32a-4e45-818d-39cef330c731.eCollection 2013. PMID 23950817
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  24. Kohli L, Lavalley N, Kaza N, Turner K, Byer SJ, Carroll SL and Roth KA. The pan erbB inhibitor PD168393 enhances lysosomal dysfunction-induced apoptotic death in MPNST cells. Neuro-Oncology 2012; 14(3): 266-277. PMID: 22259051 PMCID: PMC3280808
  25. Carroll SL. Parsing out reality from genetically engineered mouse models of neurologic diseases (editorial). Brain Research Bulletin 2012; 88: 1-2. PMID: 22487881
  26. Brossier NM, Byer SJ, Peavler LT and Carroll SL. ErbB membrane tyrosine kinase receptors: analyzing migration in a highly complex signaling system. In: Neuromethods: Protein Kinase Technologies (Mukai H, Ed; Springer Humana Press, New York) 2012; pp. 105-131.
  27. Liu R-M, van Groen T, Katre A, Cao D, Kadish I, Ballinger C, Wang L, Carroll SL and Li L. Knockout of plasminogen activator inhibitor 1 gene reduces cerebral amyloid beta peptide burden in a mouse model of Alzheimer’s disease. Neurobiology of Aging 2011; 32(6): 1079-1089. PMID: 19604604 PMCID: PMC2888674
  28. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Carlson CS, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JSK, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns N, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilman S, Giordani B, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon W, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Teri L, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA and Schellenberg GD. Common variants in MS4A4/MS4A6E, CD2AP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease. Nature Genetics 2011; 43(5): 436-441. PMID: 21460841 PMCID: PMC3090745
  29. Turk AN, Byer SJ, Zinn KR and Carroll SL. Orthotopic xenografting of human luciferase-tagged malignant peripheral nerve sheath tumor cells for in vivo testing of candidate therapeutic agents. Journal of Visualized Experiments 2011; 49: http://www.jove.com/index/Details.stp?ID=2558, doi: 10.3791/2558. PMID: 21460792 PMCID: PMC3197311
  30. Byer SJ, Eckert JM, Brossier NM, Clodfelder-Miller BJ, Turk AN, Carroll AJ, Kappes JC, Zinn KR, Prasain JK and Carroll SL. Tamoxifen inhibits malignant peripheral nerve sheath tumor growth in an estrogen receptor-independent manner. Neuro-Oncology 2011; 13(1): 28-41. PMID: 21075781 PMCID: PMC3018903
  31. Jun G, Naj AC, Beecham GW, Wang LS, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin MD, Friedland R, Inzelberg R, Kramer P, Rogaeva E, St George-Hyslop P, Cantwell LB, Dombroski BA, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Lunetta KL, Martin ER, Montine TJ, Goate AM, Blacker D, Tsuang DW, Beekly D, Cupples LA, Hakonarson H, Kukull W, Foroud TM, Haines J, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD; Alzheimer's Disease Genetics Consortium, Arnold SE, Baldwin CT, Barber R, Beach T, Bigio EH, Bird TD, Boxer A, Burke JR, Cairns N, Carroll SL, Chui HC, Clark DG, Cotman CW, Cummings JL, Decarli C, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Gearing M, Geschwind DH, Ghetti B, Gilman S, Giordani B, Glass J, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman A, Lopez OL, Mack WJ, Markesbery W, Marson DC, Martiniuk F, Masliah E, McKee AC, Mesulam M, Miller JW, Miller BL, Miller CA, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon W, Quinn JF, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider JA, Schneider LS, Seeley W, Shelanski ML, Smith CD, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Woltjer RL, Younkin SG. Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer’s disease risk loci and reveals interactions with APOE genotypes. Archives of Neurology 2010; 67(12): 1473-1484. PMID: 20697030 PMCID: PMC3048805
  32. Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, al-Sarraj S, Troakes C, Rosenberg RN, White CL III, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, de Munain AL, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, Decarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñon MT, Martinez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM. Common genetic variants at 7p21 associate with frontotemporal degeneration with TDP-43 inclusions. Nature Genetics 2010; 42(3): 234-239. PMID: 20154673 PMCID: PMC2828525
  33. Eckert JM, Byer SJ, Clodfelder-Miller BJ and Carroll SL. Neuregulin-1ß and neuregulin-1a differentially affect the migration and invasion of malignant peripheral nerve sheath tumor cells. Glia 2009; 57(14): 1501-1520. PMID: 19306381 PMCID: PMC2744852
  34. Carroll SL. Wallerian degeneration. In: Encyclopedia of Neuroscience (Squire LR, Ed; Academic Press, Oxford) 2009, volume 10, pp. 485-491.
  35. Prasain JK, Arabshahi A, Moore R, Barnes S and Carroll SL. A liquid chromatography mass spectrometry assay for determination of PD168393, a specific and irreversible inhibitor of erbB membrane tyrosine kinases, in rat serum. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 2008; 876(2): 219-24. PMID: 19010087 PMCID: PMC2785089
  36. Carroll SL and Ratner N. How does the Schwann cell lineage form tumors in NF1? Glia 2008; 56(14): 1590-1605. PMID: 18803326 PMCID: PMC2652636
  37. Ness JM, Harvey CR, Washington JD, Roth KA, Carroll SL and Zhang J. Differential activation of c-Fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemia. Journal of Neuroscience Research 2008; 86(5): 1115-1124. PMID: 18030677 PMCID: PMC3733558
  38. Akhtar RS, Geng Y, Klocke BJ, Latham CB, Villunger A, Michalak EM, Strasser A, Carroll, SL, and Roth KA. BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death. The Journal of Neuroscience 2006; 26(27):7257-7264. PMID: 16822983
  39. Ricart K, Pearson RJ Jr, Viera L, Cassina P, Kamaid A, Carroll SL, and Estevez AG. Interactions between ß-neuregulin and neurotrophins in motor neuron apoptosis. Journal of Neurochemistry 2006; 97(1):222-233. PMID:16524373
  40. Stonecypher MS, Chaudhury AR, Byer SJ and Carroll SL. Neuregulin growth factors and their erbB receptors form a potential signaling network for schwannoma tumorigenesis. Journal of Neuropathology and Experimental Neurology 2006; 65(2):162-175. PMID: 16462207
  41. Stonecypher MS, Byer SJ, Grizzle WE and Carroll SL. Activation of the neuregulin-1/erbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors. Oncogene 2005; 24(36):5589-5605. PMID: 15897877
  42. Ritch PS, Carroll SL and Sontheimer H. Neuregulin-1 enhances survival of human astrocytic glioma cells. Glia 2005; 51(3):217-228. PMID: 15812817 PMCID: PMC2548407
  43. Joung I, Harber GJ, Gerecke KM, Carroll SL, Collawn JF, and Engler JA. Improved gene delivery into neurological cells using a fiber-modified adenovirus vector. Biochemical and Biophysical Research Communications 2005; 328(4):1182-1187. PMID: 15708001
  44. Carroll, SL and Stonecypher MS. Tumor suppressor mutations and growth factor signaling in the pathogenesis of NF1-associated peripheral nerve sheath tumors. II. The role of dysregulated growth factor signaling. Journal of Neuropathology and Experimental Neurology 2005: 64(1):1-9. PMID: 15715079
  45. Gerecke KM, Wyss JM, and Carroll SL. Neuregulin-1ß induces neurite extension and arborization in cultured hippocampal neurons. Molecular and Cellular Neuroscience 2004; 27(4):379-393. PMID: 15555917.
  46. Carroll SL, Byer SJ, Dorsey DA, Watson MA, and Schmidt RE. Ganglion-specific patterns of diabetes-modulated gene expression are established in prevertebral and paravertebral ganglia prior to the development of neuroaxonal dystrophy. Journal of Neuropathology and Experimental Neurology 2004; 63 (11):1144-1154. PMID: 15581182.
  47. Carroll, SL, and Stonecypher MS. Tumor suppressor mutations and growth factor signaling in the pathogenesis of NF1-associated peripheral nerve sheath tumors. I. The role of tumor suppressor mutations. Journal of Neuropathology and Experimental Neurology 2004; 63(11):1115-1123. PMID: 15581179.
  48. Pearson RJ Jr and Carroll SL. ErbB transmembrane tyrosine kinase receptor expression in sensory and motor neurons. Journal of Histochemistry and Cytochemistry 2004; 52(10):1299-1311. PMID: 15385576.
  49. Fallon KB, Havlioglu N, Hamilton LH, Cheng TPH, and Carroll SL. Constitutive activation of the neuregulin-1/erbB signaling pathway promotes the proliferation of a human neuroepithelioma cell line. Journal of Neuro-Oncology 2004; 66: 273-284. PMID: 15015657
  50. Roysommuti S, Carroll SL, and Wyss JM. Neuregulin-1ß modulates in vivo entorhinal-hippocampal synaptic transmission in adult rats. Neuroscience 2003; 121(3):779-785. PMID: 14568036
  51. Huijbregts RPH, Roth KA, Schmidt RE, and Carroll SL. Hypertrophic neuropathies and malignant peripheral nerve sheath tumors in transgenic mice overexpressing glial growth factor-ß3 in myelinating Schwann cells. The Journal of Neuroscience 2003; 23(19):7269-7280. PMID: 12917360
  52. Frohnert PW, Stonecypher MS, and Carroll SL. Constitutive activation of the neuregulin-1/erbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line. Glia 2003; 43:104-118. PMID:12838503
  53. Ritch PA, Carroll SL, and Sontheimer H. Neuregulin-1 enhances motility and migration of human astrocytic glioma cells. Journal of Biological Chemistry 2003; 278(23):20971-20978. PMID: 12600989
  54. Frohnert PW, Stonecypher MS, and Carroll SL. Lysophosphatidic acid promotes the proliferation of adult Schwann cells isolated from axotomized sciatic nerve. Journal of Neuropathology and Experimental Neurology 2003; 62(5):520-529. PMID: 12769191
  55. Chaudhury AR, Gerecke KM, Wyss JM, Morgan DG, Gordon MN, and Carroll SL. Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer’s disease brain and in a transgenic model of Alzheimer’s disease. Journal of Neuropathology and Experimental Neurology 2003; 62(1):42-54. PMID: 12528817
  56. Gerecke KM, Wyss JM, Karavanova I, Buonanno A, Carroll SL. ErbB transmembrane tyrosine kinase receptors are differentially expressed in the adult rat central nervous system. Journal of Comparative Neurology 2001; 433(1):86-100. PMID: 11283951 Honig LS, Chambliss DD, Bigio EH, Carroll SL, and Elliott JL. Glutamate transporter EAAT2 splice variation occurs not only in ALS, but also in normal, Alzheimer and Lewy Body brains. Neurology 2000; 55:1082-1088. PMID: 11071482
  57. Nataf S, Carroll SL, Wetsel R, Szalai AJ, Barnum SR. Attenuation of experimental autoimmune demyelination in complement-deficient mice. Journal of Immunology 2000; 165:5867-5873. PMID: 11067947
  58. Carroll SL, Frohnert PW. Expression of JE (monocyte chemoattractant protein-1) is induced by axotomy in wild type rodents, but not in C57 BL/Wlds mice. Journal of Neuropathology and Experimental Neurology 1998; 57:915-930. PMID: 9786242
  59. Schmidt RE, Dorsey DA, Selznick LA, DiStefano PS, Carroll SL, Beaudet LN, Roth KA. Neurotrophin sensitivity of prevertebral and paravertebral rat sympathetic autonomic ganglia. Journal of Neuropathology and Experimental Neurology 1998; 57:158-167. PMID: 9600208
  60. Gokden M, Roth KA, Carroll SL, Wick MR, Schmidt RE. Clear cell neoplasms and pseudoneoplastic lesions of the central nervous system. Seminars in Diagnostic Pathology 1997; 14:253-269. PMID: 9383825
  61. Carroll SL, Miller ML, Frohnert PW, Kim SS, Corbett JA. Expression of neuregulins and their putative receptors, erbB2 and erbB3, is induced during Wallerian degeneration. The Journal of Neuroscience 1997; 17:1642-1659. PMID: 9030624
  62. Nevo Y, Pestronk A, Lopate G, Carroll SL. Neuropathy of metachromatic leukodystrophy: Improvement with immunomodulation. Pediatric Neurology 1996; 15:237-239. PMID: 8916163
  63. Carroll SL, Schweitzer JB, Holtzman DM, Miller ML, Sclar GM, Milbrandt J. Elements in the 5’ flanking sequences of the mouse low affinity NGF receptor gene direct appropriate CNS, but not PNS, expression in transgenic mice. The Journal of Neuroscience 1995; 15:3342-3356. PMID: 7751914
  64. Mu X, Silos-Santiago I, Carroll SL, Snider WD. Neurotrophin receptor genes are expressed in distinct patterns in developing dorsal root ganglia. The Journal of Neuroscience 1993; 13:4029-4041. PMID: 8366358
  65. Wanaka A, Carroll SL, Milbrandt J. Developmentally regulated expression of pleiotrophin, a novel heparin binding growth factor, in the nervous system of the rat. Developmental Brain Research 1993; 72:133-144. PMID: 8453763
  66. Carroll SL, Silos-Santiago I, Frese SE, Ruit KG, Milbrandt K, Snider WD. Dorsal root ganglion neurons expressing trk are selectively sensitive to NGF deprivation in utero. Neuron 1992; 9:779-788. PMID: 1389185
  67. Fahrner TJ, Carroll SL, Milbrandt JD. The NGFI-B protein, an inducible member of the thyroid/steroid receptor family, is rapidly modified posttranslationally. Molecular and Cellular Biology 1990; 10(12):6454-6459. PMID: 2247065 PMCID: PMC362922
  68. Carroll SL, Roth KA, Gordon JI. Liver fatty acid binding protein gene expression in human colorectal neoplasms: A marker for studying differentiation in gut epithelial neoplasms. Gastroenterology 1990; 99:1727-1735. PMID: 1699834
  69. Carroll SL, Bergsma DJ, Schwartz RJ. A 29 nucleotide DNA segment containing an evolutionary conserved motif is required in cis for cell-type restricted repression of the chicken ?-smooth muscle actin gene core promoter. Molecular and Cellular Biology 1988; 8:241-250. PMID: 3336359 PMCID: PMC363109
  70. Bergsma DJ, Carroll SL, Schwartz RJ. Transcriptional regulation of the chicken skeletal ß-actin gene: inverted 16bp CCAAT-box associated repeats are important components of a cell-type specific promoter and evidence for a novel element. In: Mechanisms of Control of Gene Expression-UCLA Symposium on Molecular and Cellular Biology (Siddiqui MAQ, Cullen B, Gage P, Skalka AM, Weissbach H, Eds.; Alan R. Liss, Inc., New York) 1988; pp. 97-116.
  71. Putkey JA, Carroll SL, Means AR. The nontranscribed chicken calmodulin pseudogene crosshybridizes with mRNA for the slow muscle troponin C gene. Molecular and Cellular Biology 1987; 7:1549-1533. PMID: 3037328 PMCID: PMC365245
  72. Carroll SL, Bergsma DJ, Schwartz RJ. Structure and complete nucleotide sequence of the chicken ?-smooth muscle (aortic) actin gene: An actin gene which produces multiple mRNAs. Journal of Biological Chemistry 1986; 261:8965-8976. PMID: 3013870
  73. Carroll SL, Rowley DR, Chang CH, Tindall DK. Exchange assay for androgen receptors in the presence of molybdate. Journal of Steroid Biochemistry 1984; 21:353-359. PMID: 6387280
  74. Jacobs JS and Carroll SL. Effects of temperature on the heart rate - ventilatory response in the copperhead, Agkistrodon contortrix (Reptilia: Viperidae). Journal of Thermal Biology 1982; 7:117-120.
  75. Brosius SN, Turk AN, Byer SJ, Brossier NM, Kohli L, Whitmire A, Mikhail FM, Roth KA and Carroll SL. Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesis. Acta Neuropathologica 2013 (In press). PMID: 24232507
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Carroll A. Campbell, Jr. Neuropathology Laboratory (Brain Bank)

Department of Pathology and Laboratory Medicine Chairman Dr. Steven L. Carroll
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